The Seignalet Diet PLUS  (pronounce it "Saynyalay")

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Dr. Jean Seignalet

Dr. Jean Seignalet, (photo taken at the beginning of his diet trials)


Here are Dr. Seignalet's "disease tables" showing the success rate for each of 91 diseases

Table 1. Autoimmune diseases (35)

Table 2. "Clogging diseases" (29)
....Osteoarthritis, Diabetes 2, Migraines, Overweight, Parkinson's, Fibromyalgia, Depression..........etc.etc.etc.

Table 3. "Elimination diseases" (24)
.............Colitis, Crohn's, Psoriasis, Hay Fever, Mouth Ulcers, Asthma, Eczema, Acne.....etc. etc. etc.

Table 4. "Complex diseases" (2)
SAPHO syndrome, Behçet's

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A French professor of medicine and his miracle “Seignalet diet” which reversed 91 “incurable”, chronic diseases

Dr. Jean Seignalet (Pronounce it “Shon Saynyalay”) was a French professor of medicine who devised and trialled a “hypotoxic” diet with 2,565 patients with 115 different, so called “incurable” diseases over a period of twenty years. 91 of the diseases responded to treatment with the diet and there were 1,631 complete remissions. 2,300 patients improved. The diet was not originally intended to be for weight loss but this was found to be one of the many beneficial side-effects, including increased mental alertness and poise, lowering of cholesterol and many other good things including avoidance of heart attack and stroke, cancer and Alzheimer's! To see a list of disease treated by Dr. Seignalet and click on your own to see his results for that particular disease, click here.

Before and After the Seignalet diet

"Modern" foods cause leaky gut

Dr. Seignalet believed that all the diseases which responded to his diet were caused by “leaky gut”. (Proper medical term: intestinal permeability) and that the leaky gut itself was caused by the foods that became staples during the neolithic period starting 10,000 years ago in the middle east and 5,000 years ago in Europe, with the advent of modern industrial food production aggravating the situation still further.

Time between our caveman ancestors and us – "the blink of an eye"

We are genetically adapted to foods that our cave people ancestors ate. You can consider human evolution from the viewpoint of the primates starting 75 million years ago, or from the time our first human-like ancestors, the australopithecines evolved 6 million years ago or from the time the first “early modern humans” evolved, 65,000 years ago (or even earlier) in Africa, crossing over into Europe and Asia 45,000 years ago. However you look at it, 10,000 or 5,000 years is just the blink of an eye in evolutionary terms. Our digestive enzymes have evolved to process the foods our cavemen ancestors were eating - not what we put on our tables today.

How man evolved

Digestive enzymes – the lock and key effect

Dr. Seignalet pointed out that molecules of food fit these enzymes like a lock and key, with the food being the key and the enzyme the lock. Caramel, for example, made by heating sugar, produces a mirror image, cis form that our enzymes simply cannot process. Put another way it's like trying to put a left hand into a right handed glove. Eating foods that we cannot digest properly damages the junctions between the cells (enterocytes) of the intestinal wall. Undigested macromolecules and bacterial peptides can then enter the blood stream, ending up in the cells of tissue, and the spaces (interstices) between cells, clogging up the tissue, meaning it functions less well than nature intended. Particularly dangerous are Maillard molecules, produced by grilling, frying and baking.

How Enzymes work

Which disease we then get depends on our genetic susceptibility to that disease and the type of food waste which is penetrating the gut wall.

The 4 different pathologies caused

In some cases, like Osteoarthritis for example, this simply results in the “clogging” pathology I've just described. In other cases, like Rheumatoid arthritis, it results in an “autoimmune” pathology. In fact the body is not attacking itself, as we have been told to believe by orthodox medicine but is instead attacking these waste particles of undigested food, causing inflammation. Seignalet considered that the correct term for this pathology was Xenoimmune with true autoimmune pathology being extremely rare. In other diseases like Eczema or Asthma for example, the body tries to rid itself of these wastes through its various elimination channels (medical term: emunctories), like the liver, kidneys, skin etc. Seignalet called these diseases “elimination” pathologies. In some rare diseases such as Behçet's disease or Sapho Syndrome, more than one type of pathology can be involved. Seignalet called these “complex” diseases.

How the diet works and detox symptoms

By adopting the diet of our paleolithic ancestors as much as possible, what Seignalet called the “ancestral”, or “original” or “hypotoxic” diet, the gut wall will heal. What this means is that the junctions between the enterocytes become tight again, with the result that dangerous macromolecules can no longer penetrate the gut wall and end up in the bloodsteam and then the tissue. As the gut wall heals, the flow of dangerous macromolecules is halted and a process of “detoxification” then starts in the body's tissues as these macromolecules are gradually eliminated by the immune system. As you heal, you may experience some “detox” symptoms like nausea, headaches or a loose bowel. Quite often there will be a brief, sometimes painful flare of your symptoms. These occasional symptoms will pass. They will decrease in intensity until they disappear and are to be welcomed as signs that your body is healing. These detox symptoms result from the fact that more of these “toxins” are being released into the bloodstream than the liver and kidneys are able to process and eliminate at any one time. Unfortunately, the concept of detoxification is not admitted by orthodox physicians, who might diagnose them as symptoms of “intoxification” caused by microbes or parasites or chemical toxins or even nutritional deficiencies. The best thing to do if you have detox symptoms, when you usually have little appetite anyway, is just do do an impromptu fast for a day or two while drinking plenty of pure water. (Note: the Seignalet diet is perfectly balanced and will not result in nutritional deficiencies).

Is this the “paleo diet”? Yes and no.

Is this the “Paleo diet”? Not really. The Cordain/Wolf version of the Paleo diet differs from the Seignalet diet in two important aspects. The so-called Paleo diet bans all grains and pulses. Seignalet studied each food according to how it is processed by our bodies. While he found that wheat, corn (maize), oats etc. were to be avoided, buckwheat, quinoa and rice can be consumed. Cordain and Wolf advocate eating a high proportion of cooked animal protein. Seignalet found that animal protein cooked above 110 °C or 230 °F is a disease factor. See my translation of his dangers of cooking here.

Most of us, in contrast to our cavemen ancestors, live sedentary lives and Seignalet advised eating animal protein (raw or steamed) just once a day. Note also that the Cordain/Wolf diet is mainly a lifestyle diet. It has not been trialled as a therapy to reverse disease. The Seignalet diet is designed specifically as a therapeutic diet to reverse and prevent disease. It is not touted as a cure however. To maintain remission, the diet must be adopted for life. I personally (Chris Parkinson) use it as a lifestyle diet and I incorporate Hay/Shelton/Diamond et al food combining principles as well.

Click on your disease

To see a list of disease treated by Dr. Seignalet and click on your own to see his results for that particular disease, click here.

This book written by Dr. Seignalet's daughters one of whom is a physician, and translated by myself, will tell you how to follow the Seignalet diet.

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US and rest of the world

Please note: If you do not have a kindle and cannot afford the paperback, you can download a free app from Amazon to read the kindle version on your mac or pc.

Kindle app for pc

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For iphone, ipad, and ipod

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Diseases successfully treated by Dr. Seignalet with the diet :

About the author of this website

My name is Chris Parkinson, I am 66 years old. In my spare time I am a French to English translator, health nut, medical historian, researcher, blogger and polemicist. Did I mention I ski? I am the owner of a non-health related, artisan business. I translated Dr. Seignalet's daughters' guide to Dr. Seignalet's 700 page magnum opus.: “L'Alimentation ou la Troisième Médecine” (Nutrition – the third medicine). I own a well thumbed copy of Dr. Seignalet's book.

This website is independent and represents the author's own views. The author has controversial (but well founded) views about modern medicine which Dr. Seignalet's two daughters and son may not always agree with. Despite my great admiration for Seignalet, I think outcomes on the Seignalet diet can be improved in three ways.

  1. 1. He made a serious mistake in not giving the advice to freeze any meat, fish or charcuterie which is to be eaten raw, in order to kill parasites.
  2. 2. I think that like all the medical profession, he was misled by the malignant medical myth taught in medical school that iodine supplementation is toxic (Warning! do not take iodine tincture, it is a poison).
  3. 3. Research on vitamin D dating from after his death shows the importance to health of this vitamin and that most people have a serious deficiency.

See my blog here on these subjects.